Author: Ibrahim Mustafa

Hemoglobin Oxidation in Stored Blood Accelerates Hemolysis and Oxidative Injury to Red Blood Cells

Introduction: Maintaining blood supply is a challenge in blood banks. Red blood cells stored at 4 °C have issues of biochemical changes due to metabolism of cells leading to biochemical changes, collectively referred to as “storage lesions”. Oxidation of the red cell membrane leading to lysis contributes to these storage lesions. Methods: Blood bags with […]

Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo

Abstract Objectives Clinically approved iron chelators are effective in decreasing significant transfusional iron accumulation. Starch-Deferoxamine (S-DFO), a novel high molecular weight iron chelator, was produced to increase binding capacity to iron and reduce toxicity. Although its efficacy was established in one small cohort clinical trial, its potential adverse effect was not adequately addressed. Methods We […]

Genetic epidemiology of beta-thalassemia in the Maldives: 23 years of a beta-thalassemia screening program

Abstract The Maldives is an archipelago of 407,660 people according to population census of 2014, made up of 20 atolls, which has one of the highest prevalence of β-thalassemia worldwide. However, there is a dearth of studies related to β-thalassemia in the Maldives; therefore, in this study, we aimed to investigate the genetic epidemiology of […]

Role of Zebrafish in medical research

In biomedical research always it is a challenge to find an experimental model to test various innovative drugs. In modern-day hematology, research zebrafish demonstrated its suitability and complex nature of known physiological functions of zebrafish has some resemblance to humans that makes these tiny fish in the forefront of cutting edge modern research. The blood […]

Zebrafish larvae as a model to demonstrate secondary iron overload

Abstract Objectives Thalassemia is the most common genetically inherited blood disorder arising from a defect in hemoglobin production, resulting in ineffective erythropoiesis and severe hemolytic anemia. While transfusion therapy corrects the anemia, it gives rise to secondary iron overload. Current iron chelation therapy performed using deferoxamine, and the efficiency of this drug was demonstrated here […]

Time Dependent Assessment of Morphological Changes: Leukodepleted Packed Red Blood Cells Stored in SAGM

Usually packed red blood cells (pRBCs) require specific conditions in storage procedures to ensure the maximum shelf life of up to 42 days in 2–6°C. However, molecular and biochemical consequences can affect the stored blood cells; these changes are collectively labeled as storage lesions. In this study, the effect of prolonged storage was assessed through […]

Incidence of blood groups among blood donors in Maldives

Prevalence of blood groups among different ethnic groups have variation in different part of the world. There is no published data about the prevalence of blood groups in Maldives. The data shown here is the incidence trend among blood donors in blood bank at Maldivian Blood Services. As expected O Rh+ blood group is most […]

Maldives World “hot spot” for Thalassemia

Maldives is a world ‘hot spot’ for thalassemia. The prevalence of b-thalassemia in the population of this country is 18.1%; 1 in 5 people are carriers of the disease and 1 in 120 live births are estimated to be thalassemia majors. Currently, there are more than 700 thalassemia major patients who require regular blood transfusions, […]

Cancer Awareness Program in Hulhmeedhoo

Cancer awareness workshop held in Adducity Hulhumeedhoo on 22-23rd June 2012. The target audience was women of age group 21-45. The areas covered on this workshop were introduction of cancer, and common predisposing factors for cancer. Major areas covered among most common female cancers were cervical cancer, uterine and breast cancer.