Author: Ibrahim Mustafa

The Crisis of Iron in Transfusion Medicine: Improved Iron Chelation Therapy and its Implications For Clinical Practice in the Maldives

Name: Ibrahim Mustafa Date: Monday, July 18, 2011 at 9:00 AM Place: Room 203 of the Graduate Student Centre Abstract The Maldives has one of the highest incidences of ß thalassemia in the world. Treatment of ß thalassemia is characterized by two distinct phases: treatment of nature’s disease (anemia) and the secondary treatment of transfusional […]

Saga of thalassemia-Maldivian perspectives

Ibrahim Mustafa National Thalassemia Centre, Male’ Maldives Maldives is a country with a distinctive geography that portrays a model of a small island nation. The total landmass of the 1190 small islands of the country is less than one percent of its national territory. Population of the 200 inhabited islands varies considerably. The country’s 2000 […]

Effect of Iron on Antigen Presenting Cells: Implications For Transfusion Dependent Hemoglobinopathies.

Ibrahim Mustafa, Duncheng Wang and Mark D. Scott Canadian Blood Services and the Centre for Blood Research and the Department of Pathology and Laboratory Medicine at the University of British Columbia, Vancouver, BC, Canada Background: The thalassemias and Sickle Cell Disease (SCD) are characterized by destabilized hemoglobin that can lead to a potentially life-threatening anemia. […]

Immunological Inhibition Arising From Misplaced Iron: Implications for Thalassemia and Sickle Cell Disease

I. Mustafa, D. Wang and M.D. Scott Canadian Blood Services and the Centre for Blood Research and the Department of Pathology and Laboratory Medicine at the University of British Columbia, Vancouver, BC, Canada Background: The thalassemias and Sickle Cell Disease (SCD) arise from mutations to the globin subunits of adult hemoglobin (HbA) resulting in destabilized […]

Fe3+ as a potent accelerator for hemoglobin oxidation in vitro and prooxidant effects of reduced glutathione (GSH).

Authors: Mustafa, I. and Scott, M.D. Department of Pathology and Laboratory Medicine and the Centre for Blood Research at the University of British Columbia and the Canadian Blood Services. Abstract Iron is an essential trace element for all living cells.Indeed, iron cores constitute the functional sites of many enzymes and proteins involved in generating energy, […]

Iron Shuttle Chelation Therapy: A Novel Approach To Treating Hemoglobinopathies

I. Mustafa, N. Rossi, J. N. Kizhakkedathu and M.D. ScottCanadian Blood Services and the Centre for Blood Research and the Department of Pathology and Laboratory Medicine at the University of British Columbia, Vancouver, BC, Canada Background: Thalassemias arise from deficiency of the globin subunits of adult hemoglobin (HbA) and results in ineffective erythropoiesis and the […]